Zero Escape has a special place in my heart, primarily because it was the first visual novel that truly opened my eyes to the ellusive video game genre. Now visual novels have become one of my favorite types of games, and I'm always clammoring for more to be localized in English. That's why I can't stress it enough: if you're a gamer who's even a tiny bit curious about Japanese visual novels, the Zero Escape series is a great starting point. It's got a great balance of story and puzzle, and though not all visual novels follow that exact formula, I found it to be particularly effective for a first-time western gamer such as myself (who expected some level of interaction in a video game).
Needless to say I have extremely high hopes for Zero Time Dilemma, and I doubt I'll be disappointed. It's sad to see the series end, but you know what they say about all good things. ;)